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Plasmid DNA Manufacturing Market Overview
Plasmids are circular, double-stranded DNA molecules that exist autonomously within the bacterial cells, independent of the chromosomal DNA. These genetic components have the ability to replicate independently.
The global plasmid DNA manufacturing market size is estimated to grow from USD 102 million in 2023 to USD 539 million by 2035, representing a CAGR of 14.85% during the forecast period 2023-2035.
Additionally, plasmids often carry non-essential genetic information that confers supplementary traits to host organisms. This genetic autonomy, combined with its compact circular structure, lends plasmid DNA unparalleled versatility and utility. Furthermore, its role in the development of recombinant proteins and therapeutic agents has significantly influenced the landscape of modern medicine. It is worth highlighting that 50% of the acquisition deals in Plasmid DNA Manufacturing Market are inked with the purpose of geographical expansion.
Plasmid DNA Manufacturing Market Competitive Landscape
Key players in Plasmid DNA Manufacturing Market are AGC Biologics, Aldevron, Biomay, Catalent Pharma Solutions, Charles River, Cytovance Biologics, Forge Biologics, GenScript ProBio, Thermo Fisher Scientific, and VGXI.
Further, portfolio addition as well as expansion were identified as other key drivers. Examples of entire company acquisitions for both geographical consolidation and portfolio expansion, include (in reverse chronological order) the acquisition of e-Zyvec by PolyPlus (February 2022), Nature Technology by Aldevron (January 2022) and Vigene Biosciences by Charles River (May 2021).In order to build a sustainable competitive edge in the market, companies are actively focusing on offering end-to-end plasmid DNA services, from plasmid construction, plasmid design, plasmid engineering to manufacturing process development and optimization services.
To cope up with the current and future market demand, plasmid DNA manufacturer are actively increasing their capacity.
Plasmid DNA Manufacturing Market Segmentation
Plasmid DNA Manufacturing Market segments include Distribution by Scale of Operation (Commercial, Clinical and Preclinical), Application Area (Cell Therapy Manufacturing, Gene Therapy Manufacturing, DNA / RNA Vaccine Development, Viral Vector Manufacturing, and Other Application Areas), Therapeutic Area (Metabolic Disorders, Neurological Disorders, Oncological Disorders, Rare Disorders, and Other Disorders), and Geography (North America, Europe, Asia, Latin America, Middle East and North Africa, and Rest of the World).
Over the last few years, players have made / reported significant investments in the development and manufacturing of different grades of plasmid DNA, in order to establish a unique position and develop a competitive edge in this growing market. The majority of these investments are either focused on improving the company's capabilities by introducing new technologies or expanding the capacity of their current offerings.
Currently, the 42% of plasmid DNA manufacturing capacity is installed in facilities based in Asia. This is followed by 31% capacity installed in facilities located in North America . Further, based on the company size and grade of plasmid DNA. 45% of the global plasmid DNA contract manufacturing capacity is likely to be driven by large and very large players engaged in the manufacturing only GMP plasmid manufacturing.
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