Palmitoylethanolamide is a natural pain killer ingredient in the fatty
acid amide category and synthesized within your own body, we call it
endogenous. It is widely used in sports nutrition supplements and joint
health formulas worldwide, especially in the United States, Australia,
UK, Canada and EU countries like the Netherlands, Belgium, and Italy.
Palmitoylethanolamide is a pretty long word, if it is your first time to
come across it, you may wonder how to memorize or pronounce it. Well,
palmitoylethanolamide is a word consists of three words:
Palmitoylethanolamide powder
In our daily life, PEA (the first letter of each of the three words) is
to refer to palmitoylethanolamide for short. However, PEA itself is a
plant, and PEA protein is also applied in bodybuilding supplements as a
vegetarian source of protein content. Don’t get them wrong.
PEA has been demonstrated to bind to a receptor in the cell-nucleus (a
nuclear receptor) and exerts a great variety of biological functions
related to chronic pain and inflammation.
The IUPAC name of PEA is N-(2-Hydroxyethyl) hexadecanamide. Raw
Palmitoylethanolamide is usually in the powder form, with molecule
formula and weight as C18H37NO2 and 299.49 respectively. 544-31-0 is
Palmitoylethanolamide’s CAS Registry Number and unique chemical
identity.
Palmitoylethanolamide is practically insoluble in water and poorly
soluble in most other aqueous solvents. Therefore, you may find that
almost 99% fished dosage formulations of palmitoylethanolamide are in
capsules or soft gels.
Palmitoylethanolamide VS Phenylethylamine
In fact, they are two completely different ingredients. No relationship
is between them. Phenylethylamine or Phenylethylamine HCl is most known
as a mood and weight loss ingredient in many sports nutrition. While
Palmitoylethanolamide is popularly known as a painkiller. The connection
is that both compounds are abbreviated as PEA, and called by PEA
powder. So don’t get them wrong.
Palmitoylethanolamide vs anandamide
Many of our clients who buy bulk Palmitoylethanolamide powder are also
interested in Bulk anandamide powder and anandamide oil from us.
Therefore, what’s the relation between them?Both palmitoylethanolamide
and anandamide are endogenous fatty acid amide in our human bodies.
According to Wikipedia, PEA and related compounds such as anandamide
seem to have synergistic effects in models of pain and
analgesia.Gas-chromatography/mass-spectrometry measurements indicate
that the levels of anandamide and PEA in the skin are enough to cause a
tonic activation of local cannabinoid receptors.
In one study, the data shows that anandamide and PEA activate
pharmacologically distinct receptors and that these two substances can
be produced simultaneously in tissues. When injected together in equal
amounts, anandamide and PEA inhibited the early phase of formalin-evoked
pain behavior with a potency that was approximately 100-fold greater
than each of the compounds separately (Fig. 3a). A similar synergistic
potentiation occurred in the late phase, on which anandamide had no
effect when given alone (Figs 1a and 3b). Earlier administration of
either CB1 or CB2 antagonists entirely blocked the response.
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